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Strain Detail Sheet

Strain Name:
B6NCrl.Cg-Plp1jp/KanMmjax
Stock Number:
050604-JAX
Citation ID:
RRID:MMRRC_050604-JAX
Other Names:
Plp1jp ("jimpy")

Strain Information

Gene Details

Plp1jp
Name: proteolipid protein (myelin) 1; jimpy
Synonyms: jp
Type: Allele
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Spontaneous Mutation
Plp1
Name: proteolipid protein (myelin) 1
Synonyms: DM20, Plp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Spontaneous Mutation
NCBI: 18823
HGNC: HGNC:9086
Homologene: 448

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
Sequence analysis showed that this allele carries an A-to-G base change at the 3' splice acceptor site of intron 4.
Genotype Determination

Strain Description

Phenotype
Plp1jp is a historic spontaneous mutation in the Plp1 gene that is already deposited at JAX as part of Strain #000287 on a rather mixed background. The allele has been maintained on a clean C57Bl/6NCrl background in the Nave Department for at least 28 generations since 2007.

The Plp1 gene is located on the X-chromosome, so hemizygous males show the severe phenotype described under stock 000287. Only heterozygous females can be used or breeding and cryopreservation.
Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
MeSH Terms
  • Animals
  • Bacteriophage lambda/genetics
  • Base Sequence
  • DNA/genetics
  • DNA, Recombinant
  • Exons
  • Female
  • Humans
  • Mice
  • Mice, Jimpy
  • Molecular Sequence Data
  • Mutation
  • Myelin Proteins/genetics
  • Myelin Proteolipid Protein
  • Plasmids
  • RNA, Messenger/genetics
Strain Development
Plp1jp mice were obtained from The Jackson Laboratories in the 1990s and maintained on a C57BL/6N background by mating heterozygous females to C57BL/6N males. Since 2007, the line has been backcrossed for at least 29 generations to C57BL/6NCrl.
Suggested Control Mice
Littermates

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact csmmrrc@jax.org. Older strains may not have this information.

Research Applications

  • Models for Human Disease
  • Neurobiology

Strain Origin

Donor
Klaus-Armin Nave, Ph.D., Max-Planck-Institute of Experimental Medicine.
Primary Reference

Nave KA, Bloom FE, Milner RJ. A single nucleotide difference in the gene formyelin proteolipid protein defines the jimpy mutation in mouse. J Neurochem. 1987Dec;49(6):1873-7. (Medline PMID: 2445921)

Colony and Husbandry Information

Special Considerations

Male offspring from mating heterozygous females with C57BL/6N males are either wild-type or jimpy carriers. Carriers die at the time of weaning from severe seizures. Therefore, all male pups should be sacrificed at birth, before they develop a burdened phenotype.

Health Status Report

Cryo-recovered strains distributed by the MMRRC at JAX are shipped to the customer from the Pathogen & Opportunistic-Free Animal Room G200 - see https://www.jax.org/jax-mice-and-services/customer-support/customer-service/animal-health/health-status-reports.

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email csmmrrc@jax.org.

Appearance

Coat Color
Black
Eye
Black

Breeding

MMRRC Breeding System
Backcross
Generation
N29 (C57BL/6NCrl)
Overall Breeding Performance
Good

Reproductive Statistics

NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Undetermined X-linked
Homozygotes are fertile: N/A N/A
Hetero/Hemizygotes are fertile: Yes No
Age Reproductive Decline: Undetermined Less than 4 months
Average litter size
4-6
Recommended wean age
3 Weeks
Average Pups Weaned
Less than 4

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to csmmrrc@jax.org for more information.

A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact Ingrid Kasper-Fischer.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

A Commercial License Agreement from the Donor is required for for-profit entities to use this strain. For more information, please contact Ingrid Kasper-Fischer

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.