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We’re excited to introduce Disease Ontology (DO) search terms to the MMRRC repository! This new feature enables researchers to find mouse models using standardized disease ontology terms, making it easier to discover models associated with specific human disease classifications.

Why this matters:
  • Clearer Language - Using official disease names helps avoid confusion and maintains consistency when searching..
  • Better Connections - Disease ontology terms work across many research databases, facilitating integration of results from different sources.
  • Easier to Find What You Need - Search by disease name, related terms, or DOID terms or ID numbers, helping you quickly find the right mouse models for your research.

Most Popular Disease Ontology Terms

Looking for models related to major human diseases? These popular DOID terms are a great place to start your search:

  1. DOID:162 – Cancer
  2. DOID:9352 – Diabetes
  3. DOID:10652 – Alzheimer’s disease
  4. DOID:14330 – Parkinson’s disease
  5. DOID:2841 – Asthma
  6. DOID:1826 – Epilepsy
  7. DOID:1485 – Cystic Fibrosis
  8. DOID:114 – Heart Disease
  9. DOID:8778 – Crohn’s Disease
  10. DOID:2377 – Multiple Sclerosis

A copper-delivery drug refolds damaged brain proteins in mice, reversing Parkinson’s symptoms and offering new avenues for human treatments.

In mice exhibiting tremors, rigidity, and slowed movement, targeted copper ions acted as molecular chaperones—binding and guiding misfolded proteins back into functional shapes. Treated animals regained motor control and balance within days, highlighting potential for disease-modifying therapies in neurodegenerative disorders.

Source: Good News Network

In a groundbreaking case of personalized medicine, researchers rapidly developed a gene-editing therapy to treat a newborn with a rare and deadly liver disorder—carbamoyl-phosphate synthetase 1 (CPS1) deficiency. Using CRISPR base-editing tools, the team created a bespoke therapy in just six months after diagnosis. The therapy helped stabilize the infant’s health, allowing increased protein intake and reducing medication needs—even through viral illnesses that previously posed life-threatening risks.

What made this fast-track treatment possible? Mice. Specifically, gene-edited house mice played a critical role in validating the therapy before it reached the patient. Researchers engineered mice to carry the same human genetic mutation, enabling them to test both the safety and efficacy of the customized treatment. Without this preclinical mouse model, such a rapid and precise intervention would have been far riskier and less likely to receive regulatory approval.

Notably, one of the study’s authors is also a center director for the Mutant Mouse Resource & Research Centers (MMRRC), highlighting the vital connection between mouse model infrastructure and clinical innovation. This case not only shows how deeply intertwined mouse genetics are with human health breakthroughs but sets a new bar for how personalized medicine can move from bench to bedside—fast.


Paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2504747


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Welcome to the Mutant Mouse Resource & Research Centers (MMRRC) Website

The MMRRC is the nation’s premier national public repository system for mutant mice. Funded by the NIH continuously since 1999, the MMRRC archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by the biomedical research community. The MMRRC consists of a national network of breeding and distribution repositories and an Informatics Coordination and Service Center located at 4 major academic centers across the nation. The MMRRC is committed to upholding the highest standards of experimental design and quality control to optimize the reproducibility of research studies using mutant mice. The MMRRC is supported by the Office of Research Infrastructure Programs (ORIP) in the Office of the Director at NIH. More than 60,000 mutant alleles are maintained as live mice, cryopreserved germplasm, and/or mutant ES cells. Live mice are supplied from a production colony, from a colony recovered from cryopreservation, or via micro-injection of ES cells. An MMRRC facility may offer cryopreserved material for resuscitation at the recipient scientist's institution.